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Abbreviations ADRB2/β2AR β2-Adrenergic receptor AKT/PKB Protein kinase B cAMP Cyclic adenosine monophosphate CREB CAMP-response element binding protein DCT Dopachrome tautomerase EF Epimedii Folium ERK Extracellular regulated protein kinases GSK3β Glycogen synthase kinase-3 beta‌ HMVII Human melanoma cell line HEM Human epidermal melanocyte MAPK Mitogen-activated protein kinase McSCs Melanocyte stem cells MITF Microphthalmia-associated transcription factor NRF2 Nuclear factor erythroid 2 (E2)-related factor 2 PM Polygoni multiflori radix PKA Protein kinase A PTU 1-Phenyl-2-thiourea TCM Traditional Chinese medicine TA Transit-amplifying TPA 12-O-tetradecanoylphorbol-13-acetate TYR Tyrosinase TrKA Tropomyosin receptor kinase A TRP-1 Tyrosinase-related protein 1 TRP-2 Tyrosinase-related protein 2 Author contributions This review was designed by Jiabo Wang and Haiying Gong